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Type 2 diabetes I.can develop due to a mutation in the insulin receptor II.can develop in individuals with insulin resistance. III.results in hypersensitivity to insulin release. IV.are treated with drugs that decrease AMPK activity.


A) I, II, IV
B) I, II
C) II, IV
D) III, IV
E) I, IV

F) A) and D)
G) B) and C)

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Which of the following are effects of insulin secretion? I.Muscle and adipose tissue are stimulated to take up glucose. II.Glycogen synthesis increases in the liver. III.Gluconeogenesis is inhibited in the liver and kidney. IV.Lipolysis increases in the adipose tissue.


A) I, II
B) I
C) I, II, III
D) I, III
E) II, IV

F) A) and B)
G) A) and C)

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Glucose is the preferred fuel of muscles because


A) it can be metabolized under anaerobic conditions.
B) it can be generated from ketone bodies even during starvation.
C) the heart muscle uses glucose exclusively as a fuel.
D) it is the most efficient energy storage available.
E) all of the above

F) D) and E)
G) B) and D)

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Matching Choose the correct answer from the list. Not all the answers will be used. -Following prolonged starvation, ______ are used as fuel by the brain.


A) α-adrenergic receptor
B) β-adrenergic receptor
C) Cori cycle
D) urea cycle
E) leptin
F) phosphatase
G) liver
H) hormones
I) acetyl CoA
J) ketone bodies
K) urea
L) kidney
M) brain
N) pancreas

O) H) and M)
P) B) and L)

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Activation of AMPK activity is


A) accomplished by AMP induced conformational changes facilitating phosphorylation.
B) accomplished by ATP induced conformational change facilitating phosphorylation.
C) inhibited by high levels of AMP due to conformational changes burying the phosphorylation site.
D) increased by high levels of ATP due to conformational changes burying the phosphorylation site.
E) none of the above

F) C) and D)
G) All of the above

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Matching Choose the correct answer from the list. Not all the answers will be used. -______ is the degradation product of glucose, fatty acids, and ketogenic amino acids.


A) α-adrenergic receptor
B) β-adrenergic receptor
C) Cori cycle
D) urea cycle
E) leptin
F) phosphatase
G) liver
H) hormones
I) acetyl CoA
J) ketone bodies
K) urea
L) kidney
M) brain
N) pancreas

O) D) and J)
P) A) and E)

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Which of the following is FALSE relating to leptin?


A) Obese mice lacking leptin tend to overeat.
B) Leptin seems to function by different mechanisms in mice and humans.
C) Obesity in humans leads to a decrease in leptin production.
D) Obesity leads to leptin resistance.
E) none of the above

F) A) and C)
G) All of the above

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Which of the following statements is TRUE regarding the blood glucose level of non-insulin dependent diabetics tend to compare to that of normal individuals?


A) Blood glucose levels of diabetics tend to be very stable, but at a higher level.
B) Blood glucose levels of diabetics tend to be variable and higher.
C) Blood glucose levels decrease more rapidly following a meal, often dropping lower than is tolerable.
D) Blood glucose levels average the same level in diabetics, but reach higher peaks for short periods.
E) none of the above

F) B) and E)
G) B) and D)

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Which of the following is TRUE regarding pancreatic β\beta cells?


A) Insulin is secreted by the β\beta cells in response to the increase in β\beta cell glucose receptor binding.
B) Glucagon is secreted by the β\beta cells in response to the increase in β\beta cell glucose receptor binding.
C) Insulin is secreted by the β\beta cells in response to high glucose levels.
D) Insulin is secreted by the β\beta cells in response to low glucose levels.
E) Glucagon is secreted by the β\beta cells in response to high glucose levels.

F) None of the above
G) A) and D)

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Which of the following mechanisms for ATP regeneration are listed in order utilized?


A) glycolysis, phosphocreatine, oxidative phosphorylation
B) phosphocreatine, glycolysis, oxidative phosphorylation
C) phosphocreatine, oxidative phosphorylation, glycolysis,
D) phosphocreatine, oxidative phosphorylation, glycolysis, gluconeogenesis
E) none of the above

F) A) and C)
G) C) and D)

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